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Polydextrose is commonly used as a replacement for sugarstarch, and fat in commercial beverages, cakescandiesdessert mixes, breakfast cereals, gelatins, frozen desserts, puddings, and salad dressings. Polydextrose is frequently used as an ingredient in low-carb, sugar-free, and diabetic cooking recipes. It is also used as a humectantstabiliser, and thickening agent.

Polydextrose is a form of soluble fiber and has shown healthful prebiotic benefits when tested in animals. It contains only 1 kcal per gram and, therefore, is able to help reduce calories.

However, polydextrose is not universally well tolerated. Doses as low as 10g cause significantly more intestinal gas and flatulence than even psyllium.