Stevia sweeteners are derived from the leaves of the Stevia rebaudiana (Bertoni) plant, an herbal shrub native to South America. The stevia plant has been used for food and medicinal purposes for hundreds of years, and its leaves and crude extracts have been sold as dietary supplements. Purified extracts of the sweet substances found in the stevia leaf, called steviolglycosides, are considered to be generally recognized as safe (GRAS) by the U.S. Food and Drug Administration (FDA). However, whole stevia leaves and crude leaf extracts are not permitted to be sold as sweeteners in the U.S. because there is not enough toxicological information on these products, according to the FDA. Stevia sweeteners are made by extracting steviol glycosides from the leaves of the stevia plant and purifying them to remove some of the bitter attributes found in the crude extract.